Active Vitamin D<sub>3</sub> Protects Against Diabetic Kidney Disease by Regulating the JNK Signaling Pathway in Rats

Diabetic kidney disease (DKD) is an inflammatory caused by metabolic disorder. As important signaling pathway in the response, JNK plays crucial role injury DKD. Vitamin D3 can reduce reaction and delay or even reverse DKD progression. Unfortunately, mechanism which vitamin regulates pathogenesis unclear. This research established a rat model irbesartan were used as interventions. Then, urine blood biochemistry; cytokine (IL-1 IL-6), phosphorylated protein (MEK-4 JNK1/2/3) downstream factor (AP-1 ATF-2) expression assessed. We found that group showed body weight insulin secretion significantly decreased; increased FPG, HOMA-IR lipids; 24-h urinary (UPro) compared with normal group. Additionally, levels of IL-1 IL-6 proteins elevated. These changes improved D3, especially at low dosage. results suggest active protects against rats reducing release, downregulating pathway, inhibiting transcription AP-1- ATF-2-mediated damage. provides new theoretical support for treatment diabetic nephropathy.